понедельник, 5 марта 2012 г.

Glycosylphosphatidylinositol-deficient stem cells avoid immune attack in paroxysmal nocturnal hemoglobinuria patients.

2003 JAN 30 - (NewsRx.com & NewsRx.net) -- According to a study from Japan, "Paroxysmal nocturnal hemoglobinuria (PNH) is a hematopoietic stem cell disorder in which clonal cells defective in glycosylphosphatidylinositol (GPI) biosynthesis are expanded, leading to complement-mediated hemolysis. PNH is often associated with bone marrow suppressive conditions, such as aplastic anemia. One hypothetical mechanism for the clonal expansion of GPI- cells in PNH is that the mutant cells escape attack by autoreactive cytotoxic cells that are thought to be responsible for aplastic anemia."

"Here we studied two model systems. First, we made pairs of GPI+ and GPI- EL4 cells …

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